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When they are injected with substance P, however, the pain signaling works as it does in other mammals, but only with capsaicin and not with acids.

This is proposed to be an adaptation to the animal living in high levels of carbon dioxide due to poorly ventilated living spaces, which would cause acid to build up in their body tissues.

For example, cold naked mole-rats huddle together or seek shallow parts of the burrows that are warmed by the sun.

Conversely, when they get too hot, naked mole-rats retreat to the deeper, cooler parts of the burrows.

The combination of p16 and p27 in naked mole-rat cells is a double barrier to uncontrolled cell proliferation, one of the hallmarks of cancer.

In 2013, scientists reported that the reason naked mole-rats do not get cancer can be attributed to an "extremely high-molecular-mass hyaluronan" (HMW-HA) (a natural sugary substance), which is over "five times larger" than that in cancer-prone humans and cancer-susceptible laboratory animals.

They are well-adapted to their underground existence.

Their eyes are quite small, and their visual acuity is poor.

The naked mole-rat survives for at least 5 hours in air that contains only 5% oxygen; it does not show any significant signs of distress and continues normal activity.

The longer-lived species, humans and naked mole rats, expressed DNA repair genes, including core genes in several DNA repair pathways, at a higher level than did mice.

In addition, several DNA repair pathways in humans and naked mole rats were up-regulated compared with mice.

They are thermoconformers rather than thermoregulators in that, unlike other mammals, body temperature tracks ambient temperatures.

However, it has also been claimed that "the Naked Mole-Rat has a distinct temperature and activity rhythm that is not coupled to environmental conditions." At lower temperatures, naked mole-rats can use behavioral thermoregulation.

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The skin of naked mole-rats lacks a key neurotransmitter called substance P that is responsible in mammals for sending pain signals to the central nervous system.

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