Dating of pregnancy by trimesters a review and reappraisal trouble updating windows xp

Posted by / 27-Mar-2020 19:45

Dating of pregnancy by trimesters a review and reappraisal

Intravenous anti-D has also been used effectively for therapy of ITP in pregnancy, although in only a small number of reported cases.For patients who do not respond to corticosteroids or IVIg as single agents, combinations of these therapies may sometimes be more effective, particularly when corticosteroids are delivered as high-dose “pulse” therapy (eg, methylprednisolone, 1 g/day for two consecutive days).If this approach fails, laparoscopic splenectomy may be safely performed during pregnancy.If splenectomy is needed, it should be performed during the mid-second trimester, if possible, to avoid early pregnancy loss and obstruction of the surgical field by the gravid uterus at later dates.Considerations for optimal management of the pregnant patient with thrombocytopenia will also be described.Thrombocytopenia affects 6% to 10% of all pregnant women and other than anemia is the most common hematologic disorder in pregnancy.

Generally, these individuals have mild thrombocytopenia that first becomes apparent in the mid-second to third trimester of pregnancy.Corticosteroids, the first-line of therapy for ITP in nonpregnant individuals, are equally efficacious in pregnant women, with response rates of 70% to 80%.However, corticosteroids cause several unique toxicities in pregnancy, such as gestational diabetes and pregnancy-induced hypertension.Some causes of thrombocytopenia are unique to pregnancy and may not be familiar to hematologists.In the review, we will discuss the differential diagnosis of thrombocytopenia in pregnancy, and the pathogenesis of selected thrombocytopenic disorders.

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Thrombocytopenia occurs commonly during pregnancy, and may result from diverse etiologies.